Rangers discovered the remains of two, possibly three, people in a lion enclosure in the Sibuya reserve, near the south-east town of Kenton-on-Sea.
A high-powered rifle and an axe were also found.
There has been an rise in poaching in Africa in recent years, to feed growing demand for rhino horn in parts of Asia.
In China, Vietnam and elsewhere, rhino horn is believed to have aphrodisiac qualities.
Sibuya reserve owner Nick Fox said in a statement on the reserve’s Facebook page that the suspected poachers entered the reserve late on Sunday night or early on Monday morning.
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